149 articles - From Friday Oct 06 2023 to Friday Oct 13 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
|---|
PERCEPTIONS, DEFINITIONS, AND THERAPEUTIC INTERVENTIONS FOR OCCASIONAL CONSTIPATION: A ROME WORKING GROUP CONSENSUS DOCUMENT. Occasional constipation is a unique clinical entity characterized by infrequent but recurrent symptoms. Data is limited as consensus definitions have been lacking. Establishing a standardized definition and therapeutic recommendations provides a framework for future studies focusing on epidemiologic and symptoms-based outcomes. Further studies are needed to confirm and refine these recommendations. |
| Endosc Int Open |
| Endoscopy |
Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. MR11: After successful EET, ESGE recommends the following surveillance intervals:- For patients with a baseline diagnosis of HGD or EAC:at 1, 2, 3, 4, 5, 7, and 10 years after last treatment, after which surveillance may be stopped.- For patients with a baseline diagnosis of LGD:at 1, 3, and 5 years after last treatment, after which surveillance may be stopped. Strong recommendation, low quality of evidence. |
| Gut |
British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy. Types of sedation are discussed, procedure and room requirements and the recovery period, providing guidance to enhance safety and minimise complications. These guidelines are intended to inform practising clinicians and al staff involved in the delivery of gastrointestinal endoscopy with an expectation that this guideline will be revised in 5-years' time. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Systematic review with meta-analysis: Diagnostic performance of faecal calprotectin in distinguishing inflammatory bowel disease from irritable bowel syndrome in adults. Faecal calprotectin is a reliable test in distinguishing patients with IBD from those with IBS. Faecal calprotectin seems to have a better sensitivity in Western countries and at a cut-off of =50 µg/g. |
| Clin Gastroenterol Hepatol |
Risk of Major Adverse Cardiovascular Events in Immune-Mediated Inflammatory Disorders on Biologics and Small Molecules: Network Meta-Analysis. Anti-IL-12/23, JAKi, and anti-TNF-a were associated with higher risk of MACE compared with placebo. The magnitude of the increased MACE risk was not different by IMID type. These results require confirmation in larger prospective studies. |
| Endosc Int Open |
Full-thickness resection device for management of lesions involving the appendiceal orifice: Systematic review and meta-analysis. However, appendicitis post-resection occurs in a non-trivial number of patients and the R0 resection rate in appendiceal lesions is only 72%. Therefore, caution should be employed in the use of this technique, considering the relative risks of surgical intervention in each patient. |
Underwater versus conventional endoscopic mucosal resection for colorectal lesions: An updated meta-analysis of randomized controlled trials. UEMR is a promising effective technique for removal of colorectal lesions. The most contemporary literature indicates that it improves en bloc resection rate without increasing procedure time, recurrence, or AEs (PROSPERO ID CRD42022374935). |
| Gastrointest Endosc |
Fully versus Partially-Covered Self-Expandable Metal Stents for palliation of distal malignant biliary obstruction: a meta-analysis. Despite considerable heterogeneity and small standardized differences, PC-SEMS consistently exhibited longer TRBO than FC-SEMS across analyses, without any other differences in AEs rates, potentially proposing PC-SEMS as standard comparator and TRBO as primary outcome for future randomized studies on dMBO (CRD42023393965). |
| Gut |
Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people. China has experienced remarkable decreases in HBV infection over the last four decades, but variations in HBsAg prevalence persist in subpopulations. Ongoing prevention of HBV transmission is needed to meet HBV elimination targets by 2030. |
| Hepatology |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Obeticholic acid as a second-line treatment for low phospholipid-associated cholelithiasis syndrome. These preliminary observations suggest that OCA may have the potential to effectively treat LPAC syndrome in patients with inadequate response or intolerance to UDCA. Larger studies are needed to confirm these data. |
| Am J Gastroenterol |
Clinical outcomes after endoscopic management of low-risk and high-risk T1a esophageal adenocarcinoma: A multicenter study. High-risk T1a EAC patients undergoing successful EET had a substantially higher rate of extra-esophageal metastases compared to low-risk T1a EAC on long term follow-up. These data should be factored into discussions with patients while selecting treatment approaches. Additional prospective data in this area are critical. |
Global, regional, and national burden of gastric cancer in adolescents and young adults, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. In the past 30 years, although the total number of new cases of GCAYA has increased with population growth, the ASIR and overall disease burden have shown a decreasing trend. This indicates progress in screening, diagnosis, treatment, education, and awareness efforts. However, the distribution of this disease remains uneven in terms of gender, age, development level, region, and country. To address these challenges, global health authorities should take appropriate measures such as optimizing screening programs, strengthening awareness and screening efforts for males, enhancing prevention and control among the 35-39 age group, improving infrastructure and healthcare resources in developing countries, promoting international cooperation, and implementing tailored measures. |
Maternal and Neonatal Outcomes in Vedolizumab and Ustekinumab Exposed Pregnancies: Results from the PIANO registry. This analysis of UST and VDZ exposure during pregnancy suggests no increase in complications compared to TNFs, immunomodulators and combination TNFs/immunomodulators. No signal was found for increased placental events with either therapy. Continuation of UST and VDZ throughout pregnancy is recommended. |
| Clin Gastroenterol Hepatol |
Dynamics of the Gut Mycobiome in Patients with Ulcerative Colitis. Clinical activity in UC is associated with an increased relative abundance of Candida, cross-sectionally and dynamically over time. The role of fecal Candida as a target for therapeutics in UC should be evaluated. |
Modified-release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-blind, Randomized, Placebo-controlled Trials. Despite prior evidence of beneficial effects of PC in phase 2 trials, our induction study with LT-02 in patients with mild to moderate UC was terminated prematurely for futility. Signals of efficacy in maintenance therapy require confirmation in an adequately-powered maintenance trial. LT-02 was safe and well tolerated. , Numbers NCT02280629, NCT02142725. |
Progression of Pediatric Crohn's Disease is Associated with Anti-TNF Timing and BMI Z-Score Normalization. Anti-TNF exposure up to 3 months from diagnosis may reduce B2 progression. Additionally, lack of BMIz normalization within 6 months of diagnosis is associated with increased surgery risk and a pro-inflammatory transcriptomic profile. |
Quality of life and bi-directional gut-brain interactions in irritable bowel syndrome from adolescence to adulthood. Adolescents and young adults with IBS in the general population have impaired HRQoL. Bi-directional gut-brain interactions are relevant for symptom generation in AP-DGBI, and for HRQoL impairment and psychological distress in the transition from childhood to adulthood. |
Utilization of Antiviral Therapy for Patients With Hepatitis B-Related Hepatocellular Carcinoma: A Nationwide Real-World US Study. Among patients with HBV-related HCC, only 1 in 3 received OAV despite having insurance coverage. Efforts must continue to develop ways to improve HBV OAV treatment, especially among females, non-Asian patients, and patients without cirrhosis or not seen by specialists. |
| Endosc Int Open |
Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review. AI-assisted reading has shown significant time savings without reducing sensitivity in this study. Limitations remain in the evaluation of other indicators. |
Frequency of serrated polyposis syndrome recognition by community endoscopists. SPS is the most common colorectal polyposis syndrome, but it remains underdiagnosed by community endoscopists. Underdiagnosis may contribute to post-colonoscopy colorectal cancer in patients with SPS. |
Measuring the observer (Hawthorne) effect on adenoma detection rates. The presence of an independent observer documenting colonoscopy quality metrics and video recording the colonoscopy resulted in a significant increase in ADR and other quality metrics. The Hawthorne effect should be considered an alternative strategy to advanced devices to improve colonoscopy quality in practice. |
Predictors of success of conventional ERCP for bile duct stones and need for single-operator cholangioscopy. Ductal anatomy, the presence of a stricture distal to a stone, cystic and intrahepatic stones and stones larger than the distal duct are considered by endoscopists to be significant predictors of requiring cholangioscopy-assisted lithotripsy. |
Retrospective comparison of G-EYE balloon-colonoscopy with standard colonoscopy for increased adenoma detection rate and reduced polyp removal time. Introduction of G-EYE to an SC endoscopy room yielded considerable increase in ADR and notable reduction in PRT, particularly with the EMR technique. G-EYE balloon colonoscopy might increase the effectiveness of colorectal cancer screening and surveillance colonoscopy, and can shorten the time of endoscopic intervention. |
| Endoscopy |
A real-time deep learning-based system for colorectal polyp size estimation by white-light endoscopy: development and multicenter prospective validation. Regarding inappropriate surveillance recommendations, system's error rate is also lower than that of endoscopists (1.45% vs 16.60%, p<0.0001). ENDOANGEL-CPS could potentially improve the accuracy of colorectal polyp size measurements and size-based surveillance intervals. |
| Gastroenterology |
Targeting Stem Cells and Dysplastic Features with Dual MEK/ERK and STAT3 Suppression in Gastric Carcinogenesis. Through its dual blockade of MEK/ERK and STAT3 signaling pathways, Pyrvinium can effectively induce growth arrest in metaplasia and cell death in dysplasia. Therefore, our findings suggest that Pyrvinium is a promising chemotherapeutic agent for reprogramming the pre-cancerous milieu to prevent of gastric cancer development. |
| Gastrointest Endosc |
A novel miniature transendoscopic telerobotic system for endoscopic submucosal dissection. We developed a novel transendoscopic telerobotic system, named DREAMS. The safety profile and technical feasibility of ESD were significantly improved with the assistance of the DREAMS system, especially in the narrower esophageal lumen. |
Complete Circumferential ESD for Early Barrett's Neoplasia. Multifocal dysplastic Barrett's esophagus remains a challenging entity to treat. Circumferential ESD is a possible therapeutic option, with high procedural success and low adverse outcomes. This should be balanced against the risk of stricture development, as the optimal post procedural prophylaxis regimen is investigated. |
Development of Convolutional Neural Network Models That Recognize Normal Anatomical Structures During Real-Time Radial- and Linear-Array Endoscopic Ultrasound (with Videos). The proposed CNN models accurately recognize the normal anatomical structures in prerecorded videos and real-time EUS. Prospective trials are needed to evaluate the impact of these models on the learning curves of EUS trainees. |
Prospective study of diagnostic yields of flexible spectral imaging color enhancement installed in colon capsule endoscopy for colorectal polyps and tumors. CCE-FICE improved the detection rates for al CRTs except adenocarcinomas, =10 mm and protruding polyps, when compared to CCE-WL (UMIN 000021125). |
| Gut |
Non-linear association of baseline viral load with on-treatment hepatocellular carcinoma risk in chronic hepatitis B. Patients with moderate baseline viral load, particularly around 6 log10 IU/mL, demonstrated the highest on-treatment HCC risk, despite long-term antiviral treatment. Early initiation of antiviral treatment, tailored to viral load, should be considered to minimise HCC risk in adult CHB patients without cirrhosis. |
| Hepatology |
An entropy weight method to integrate big omics and mechanistically evaluate drug-induced liver injury. This study provides a novel approach to mechanisms-driven prediction modeling, as well as big data integration for insights into pharmacology and other human biology areas.Yuan Jin and Yingqing Shou contributed equally to this manuscript. |
CYP8B1 downregulation mediates the metabolic effects of vertical sleeve gastrectomy in mice. CYP8B1 is a critical downstream target of VSG. Modulation of BA composition and GM profile by targeting CYP8B1 may provide novel insight into the development of therapies that non-invasively mimic bariatric surgery to treat obesity and its complications. |
Genomic approaches to explore susceptibility and pathogenesis of alcohol use disorder and alcohol-associated liver disease. In this review, we described multiple genomic approaches and their implications to investigate the susceptibility and pathogenesis of both AUD and ALD. We concluded our review with a discussion of the knowledge gaps and future research on genomic studies in these two diseases. |
Non-invasive assessment of hepatic decompensation. In this review, we describe the uses and pitfalls of NITs for hepatic decompensation from risk stratification in primary care to treatment decisions in outpatient clinics, as well as for the in-hospital management of patients with acute-on-chronic liver failure. We summarize which NITs to use when, for what indications, and how to maximize the potential of NITs for improved patient management. |
Noncanonical regulation of HOIL-1 on cancer stemness and sorafenib resistance identifies pixantrone as a novel therapeutic agent for hepatocellular carcinoma. HOIL-1 is critical in promoting sorafenib resistance and CSC properties of HCC through Notch1 signaling. Pixantrone targeting HOIL-1 restrains the sorafenib resistance and provides a potential therapeutic intervention for HCC. |
Risk of liver-related events in metabolic dysfunction-associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria. The risk of LRE is similar in patients with high-risk MASH and with F2-F4 fibrosis without MASH. The use of LSM=10 KPa or AGILE 3+ >0.67 could be an accurate option to identify MASLD patients worthy to be included in clinical trials. |
ZNT1 and Zn2+ control TLR4 and PD-L1 endocytosis in macrophage to improve chemotherapy efficacy against liver tumor. Our study proposes a new concept that ZNT1 and zinc regulate endosome endocytosis to maintain surface receptors and zinc supplements might be synergized with chemotherapy to treat inflammation-associated tumors, especially those containing PD-L1+ myeloid cells. |
| J Hepatol |
Incidence and predictors of hepatocellular carcinoma in patients with autoimmune hepatitis. HCC incidence in AIH is low even after cirrhosis development and is associated to risk factors as obesity, cirrhosis, and AIH/PSC variant syndrome. Impact and implications The risk of developing hepatocellular carcinoma (HCC) in subjects with autoimmune hepatitis (AIH) seems to be lower compared to other aetiologies of chronic liver disease. Yet, solid data for this specific patient group remains elusive, given that most of the existing evidence comes from small, single-centre studies. In our study, we found that HCC incidence in AIH patients is low even after the onset of cirrhosis. Additionally, factors such as advanced age, obesity, cirrhosis, alcohol consumption, and the presence of the AIH/PSC variant syndrome at the time of AIH diagnosis are linked to a higher risk of HCC. Based on these findings, there seems to be merit in adopting a specialized HCC monitoring program for AIH patients, taking into account their individual risk factors. |
Therapeutic vaccination with lentiviral vector in HBV-persistent mice and two inactive HBsAg carriers. In the two inactive HBsAg carrier patients, vaccination with LV-LHBs induced a considerable increase in the number of peripheral LHBs-specific T cells in one patient, and a weak but detectable response in the other, accompanied by a sustained reduction of HBsAg (-0.31 log10 IU/ml and -0.46 log10 IU/ml, respectively) from baseline to nadir. A lentiviral-vectored therapeutic vaccine for chronic HBV infection demonstrated the potential to improve HBV-specific T cell response and deplete HBV-positive hepatocytes, leading to a sustained loss or reduction of serum HBsAg. |
| J Neurogastroenterol Motil |
Distinct Effects of Non-absorbed Agents Rifaximin and Berberine on the Microbiota-Gut-Brain Axis in Dysbiosis-induced Visceral Hypersensitivity in Rats. Compared with rifaximin, berberine significantly changed microbial structure and enriched , reduced the expression of peptidoglycan biosynthesis genes and increased acetate and propionate. The absence of these actions of rifaximin may explain the different effects of the drugs on microbiota-gut-brain axis. |
Non-cardiac Chest Pain in Japan: Prevalence, Impact, and Consultation Behavior - A Population-based Study. The prevalence of chest pain in this sample of a Japanese general population was 5%. Among al subjects with chest pain, less than one-third consulted physicians, approximately 70% of whom were diagnosed with NCCP. Sex and both the severity and frequency of chest pain were associated with consultation behavior. |
On-demand Versus Continuous Maintenance Treatment With a Proton Pump Inhibitor for Mild Gastroesophageal Reflux Disease: A Prospective Randomized Multicenter Study. Continuous treatment seems to be more appropriate for the initial maintenance treatment of non-erosive GERD or mild erosive esophagitis than on-demand treatment. Stepping down to on-demand treatment needs to be considered after a sufficient period of continuous treatment. |
Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational, Cross-sectional, Multicenter Study. Although overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups. |
Revisiting the Role of Esophageal Mucosal Dilated Intercellular Spaces in the Diagnosis and Pathophysiology of Heartburn. Since the IS length measurement had better discrimination power only in erosive groups, it is not feasible to use in daily routine to discriminate other nonerosive phenotypes and FH. The role of DIS in heartburn in nonerosive patients should be reconsidered. |
Spot Hydrogen Breath Test for Predicting Response to Low Fermentable Oligo-, Di-, Mono-saccharides, and Polyols Dietary Advice in Patients With Bloating. A higher baseline breath hydrogen level was associated with bloating improvement after low FODMAPs dietary advice. A spot breath test after lunch, a simple point-of-care test, is possibly helpful in managing patients with bloating. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
|---|
| Gastroenterology |
Evolving Concepts in Helicobacter pylori management. pylori eradication coupled with population-level programs for screening and treatment could be an effective and efficient strategy to prevent gastric cancer, especially in minority and potentially marginalized populations that bear the heaviest burden of H. pylori infection and its complications. |
| J Hepatol |
| J Neurogastroenterol Motil |
Modern Achalasia: Diagnosis, Classification, and Treatment. Such diagnostic innovations, along with the increased awareness by clinicians and patients due to the availability of alternative therapeutic approaches (laparoscopic and robotic Heller myotomy, and peroral endoscopic myotomy) have radically changed the natural history of the disorder. Herein, we report the most recent advances in the diagnosis, classification, and management of esophageal achalasia and underline the still-grey areas that needs to be addressed by future research to reach the goal of personalizing treatment. |
The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications. Moreover, it provides a comprehensive review of the crosstalk between the gut-brain axis and disease, whilst also discussing curcumin-mediated gut-brain axis-dependent and -independent signaling about modulation of gut microbiota dysbiosis. This will help to define the utility of curcumin as a novel therapeutic agent to regulate intestinal microflora dysbiosis. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
|---|
| Gastroenterology |
| Gut |
| J Hepatol |